Acalabrutinib

Red

Brand Name(s):

Indication:Chronic lymphocytic leukaemia

Rationale:1,2,3

Considered:May-21

Review Date:May-26

Comments:
NICE TA689
Acalabrutinib as monotherapy is recommended as an option for untreated chronic lymphocytic leukaemia (CLL) in adults, only if:
* there is a 17p deletion or TP53 mutation, or
* there is no 17p deletion or TP53 mutation, and fludarabine plus cyclophosphamide and rituximab (FCR), or bendamustine plus rituximab (BR) is unsuitable, and
* the company provides the drug according to the commercial arrangement.

Acalabrutinib as monotherapy is recommended, within its marketing authorisation, as an option for previously treated CLL in adults. It is recommended only if the company provides the drug according to the commercial arrangement.

These recommendations are not intended to affect treatment with acalabrutinib that was started in the NHS before this guidance was published. People having treatment outside these recommendations may continue without change to the funding arrangements in place for them before this guidance was published, until they and their NHS clinician consider it appropriate to stop.