Sofosbuvir

Red

Brand Name(s):Sovaldi

Indication: Hepatitis C (chronic) in adults (CHC)

Rationale:1,2

Considered:Feb-14

Review Date:Jun-20

Comments:
Drug Safety Update
Avoid concomitant use of amiodarone (Cordarone X) with ledipasvir-sofosbuvir (Harvoni), and amiodarone with sofosbuvir (Sovaldi) and daclatasvir (Daklinza), unless other antiarrhythmics cannot be given. Full information at:https://www.gov.uk/drug-safety-update/sofosbuvir-with-daclatasvir-sofosbuvir-and-ledipasvir-risks-of-severe-bradycardia-and-heart-block-when-taken-with-amiodarone
May 2015

NICE TA
Sofosbuvir (also known as Sovaldi) is recommended as a possible treatment for adults with some types (called genotypes) of chronic hepatitis C. It is taken with other drugs (peginterferon alfa and ribavirin, or ribavirin alone).Full guidance available at:
http://www.nice.org.uk/guidance/ta330/resources/guidance-sofosbuvir-for-treating-chronic-hepatitisc-pdf
Feb 2015