Sodium Oxybate

Red

Brand Name(s):Xyrem

Indication:Cataplexy in adults & children with narcolepsy

Rationale:1,2

Considered:Dec-06

Review Date:Apr-22

Comments:
Clinical Commissioning Policy 16065/P
NHS England to routinely commission sodium oxybate for narcolepsy and cataplexy in children and adolescents up to the age of 19. Commissioning of sodium oxybate in adults is the responsibility of CCGs
April 2017
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Due to the well known potential of abuse of sodium oxybate, physicians should evaluate patients for a history of or susceptibility to drug abuse prior to commencing treatment. During treatment, patients should be monitored for the risk of diversion, misuse and abuse of sodium oxybate

SPC Xyrem April 2011
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* There have been reports of dosing errors with Xyrem (sodium oxybate) due to a confusion between gram (g) and millilitre (mL) units.

* Please be aware that because the measuring syringe is uniquely graduated in g, the Xyrem dose must be expressed in g to ensure that patients will administer the correct dose.

* Xyrem should only be administered with the measuring syringe provided and the syringe should only be used to administer Xyrem.

Direct Healthcare Professional Communication regarding risk of dosing errors with Xyrem (sodium oxybate) due to a confusion between gram (g) and millilitre (mL) units

MHRA Direct Healthcare Communication August 2010