SPC update – sections 4.4 and 4.5 advise caution when used with opioids due to risk of CNS depression – this increased risk was observed at low doses of pregabalin (? 300 mg) and there was a trend for a greater risk at high doses of pregabalin.
NICE CG 173
management of Neuropathic Pain information at:http://www.nice.org.uk/nicemedia/live/14301/65756/65756.pdf
Issued November 2013