Naloxone/Oxycodone prolonged release

Grey

Brand Name(s):Targinact

Indication:Severe pain

Rationale:5

Considered:Feb-09

Review Date:Jan-25

Comments:
This drug is on the NHS England list of Items which should not routinely be
prescribed in primary care; link to document here;
https://www.england.nhs.uk/wp-content/uploads/2019/08/items-which-should-not-routinely-be-
prescribed-in-primary-care-v2.1.pdf

Oxycodone/naloxone prolonged release (PR) tablets are suitable for prescribing in primary care only for patients with severe pain and persistent opioid-induced constipation despite regular laxative therapy

For palliative care and chronic pain, reserved as second-line to formulary opioids (i.e. morphine) and laxatives

Doncaster & Bassetlaw Hospital NHS Foundation Trust Formulary Oct 2009