Ledipasvir / Sofosbuvir

Red

Brand Name(s):Harvoni

Indication:Chronic hepatitis C

Rationale:1,2

Considered:Nov-14

Review Date:Nov-20

Comments:
NICE TA 363 Ledipasvir sofosbuvir for treating chronic hepatitis C
Full information can be found at:http://www.nice.org.uk/guidance/ta363/resources/ledipasvirsofosbuvir-for-treating-chronic-hepatitis-c-82602727094725
November 2015
…………………………
Drug Safety Update
Avoid concomitant use of amiodarone (Cordarone X) with ledipasvir-sofosbuvir (Harvoni), and amiodarone with sofosbuvir (Sovaldi) and daclatasvir (Daklinza), unless other antiarrhythmics cannot be given. Full information at:https://www.gov.uk/drug-safety-update/sofosbuvir-with-daclatasvir-sofosbuvir-and-ledipasvir-risks-of-severe-bradycardia-and-heart-block-when-taken-with-amiodarone
May 2015