Imipenem with Cilastatin

Red

Brand Name(s):Primaxin

Indication:Aerobic and anaerobic gram-positive and gram-negative infections; surgical prophylaxis;hospital-acquired septicaemia

Rationale:1,2

Considered:May-10

Review Date:May-20

Comments:
Advice for healthcare professionals:
* A clinically significant interaction between carbapenems and valproic acid/sodium valproate results in reduced valproate plasma concentrations with potential for inadequate seizure control
* Given the large magnitude and rapid time course of this interaction,monitoring of sodium valproate levels or making dose adjustments are unlikely to manage this interaction
* Concomitant use of carbapenems in patients taking valproic acid/sodium valproate is not recommended, and prescribers should consider alternative antibacterial therapy

MHRA Drug Safety Update Volume 3 Issue 10 May 2010