Ibrutinib

Red

Brand Name(s):Imbruvica

Indication:Relapsed or refractory mantle cell lymphoma (MCL), Waldenstrom’s macroglobulinaemia (WM)

Rationale:1,2

Considered:Nov-14

Review Date:Jul-22

Comments:
Drug Safety Update
Reports of ventricular tachyarrhythmia; risk of hepatitis B reactivation and of opportunistic infections
Aug 17
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NICE TA429
Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation
Jan-17