Ertapenem

Red

Brand Name(s):Invanz

Indication:Infection – prevention of infections post elective colorectal surgery. Diabetic foot infections of the skin and soft tissue. Intra-abdominal infection

Rationale:1,2

Considered:May-07

Review Date:Mar-22

Comments:
Advice for healthcare professionals:
* A clinically significant interaction between carbapenems and valproic acid/sodium valproate results in reduced valproate plasma concentrations with potential for inadequate seizure control
* Given the large magnitude and rapid time course of this interaction,monitoring of sodium valproate levels or making dose adjustments are unlikely to manage this interaction
* Concomitant use of carbapenems in patients taking valproic acid/sodium valproate is not recommended, and prescribers should consider alternative antibacterial therapy

MHRA Drug Safety Update Volume 3 Issue 10 May 2010