Dimethyl fumarate

Red

Brand Name(s):Tecfidera

Indication:MS – relapsing & remitting

Rationale:1,2

Considered:May-13

Review Date:May-21

Comments:
Drug Safety Update
Risk of progressive multifocal leukoencephalopathy
April 2016
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Drug Safety update
Fatal PML in an MS patient with severe, prolonged lymphopenia. Full details at:https://www.gov.uk/drug-safety-update/dimethyl-fumarate-tecfidera-fatal-pml-in-a-ms-patient-with-severe-prolonged-lymphopenia
March 2015
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NICE CG186 Management of MS in Primary & Secondary Care:
http://www.nice.org.uk/guidance/cg186/resources/guidance-multiple-sclerosis-pdf
Oct 2014
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