Diethylstilboestrol

Red

Brand Name(s):Stilboestrol

Indication:Prostate cancer and postmenopausal women with breast cancer

Rationale:1,2,7

Considered:Nov-12

Review Date:Jan-24

Comments:
Diethylstilbestrol is sometimes used to treat prostate cancer, but it is not usually used first-line because of its side-effects. It is occasionally used in postmenopausal women with breast cancer. Toxicity is common and dose-related side-effects include nausea, fluid retention, and venous and arterial thrombosis. Impotence and gynaecomastia always occur in men, and withdrawal bleeding may be a problem in women. Hypercalcaemia and bone pain may also occur in breast cancer.

BNF October 2012