Colistimethate sodium Colistimethate Sodium for inhalation)

Red

Brand Name(s):Colobreathe dry powder inhaler device

Indication:Pseudomonas aeruginosa colonisation in patients with cystic fibrosis (CF) aged 6 years and older.

Rationale:1,2

Considered:Jul-13

Review Date:Nov-23

Comments:
NHS England Specialist Commissioning:
Prescribing to remain with specialist centre

April 2014

NICE technology appraisal guidance 276
Colistimethate sodium and tobramycin dry powders for inhalation for treating pseudomonas lung infection in cystic fibrosis
Guidance

1.2 Colistimethate sodium DPI is recommended as an option for treating chronic pulmonary infection caused by P. aeruginosa in people with cystic fibrosis only if: they would clinically benefit from continued colistimethate sodium but do not tolerate it in its nebulised form and thus tobramycin therapy would otherwise be considered and the manufacturer provides colistimethate sodium DPI with the discount agreed as part of the patient access scheme to primary, secondary and tertiary care in the NHS.
1.3 People currently using tobramycin DPI or colistimethate sodium DPI that is not recommended according to 1.1 or 1.2 should be able to continue treatment until they and their clinician consider it appropriate to stop. For children and young people this decision should be made jointly by the clinician, the child or young person and their parents or carers.
Issued: March 2013
Further information: http://www.nice.org.uk/nicemedia/live/14134/63269/63269.pdf