Canagliflozin and Metformin hydrochloride.

Green-G

Brand Name(s):Vokanamet

Indication:Diabetes Mellitus-Type 2

Rationale:

Considered:Nov-14

Review Date:Feb-24

Comments:
Drug Safety Update
SGLT2 inhibitors: reports of Fournier’s gangrene (necrotising fasciitis of the genitalia or perineum)
Feb 2019
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NICE NG28 Update Type 2 diabetes in adults: management
May 2017
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Drug Safety Update
SGLT2 inhibitors: updated advice on increased risk of lower-limb amputation (mainly toes)
Mar-17
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Drug Safety Update
signal of increased risk of lower extremity amputations observed in trial in high cardiovascular risk patients
July 2016
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Drug Safety Update
Risk of diabetic ketoacidosis
April 2016