Bendamustine

Red

Brand Name(s):Levact

Indication:Chronic lymphocytic leukaemia, multiple myeloma

Rationale:1,2,3

Considered:Apr-10

Review Date:Jul-22

Comments:
Drug Safety Update
Increased mortality observed in recent clinical studies in off-label use; monitor for opportunistic infections, hepatitis B reactivation
Jul-17
…………………………
Bendamustine is recommended as an option for
the first-line treatment of chronic lymphocytic
leukaemia (Binet stage B or C) in patients for
whom fludarabine combination chemotherapy is
not appropriate.

NICE Guidance Feb 2011